This project is led by Julie Di Cristofaro (PhD, HDR, CR EFS), Christophe Picard, (MD, PhD, HDR, EFS) and Pascal Pedini (PharmD, PhD, EFS), it benefits from many collaborations, including that with the team of Pr Pascal Chanez (APHM, INSERM, C2VN).
Projects
Based on the data from the previous project, the main objective of this project is to define the biomarkers particularly involved in the phenomena of tolerance, inflammation and rejection in order to improve the diagnostic and therapeutic management of transfused, grafted or transplanted patients as well as their donor selection.
The immunological safety of transfusions is based, among other things, on the compatibility of erythrocyte blood groups. Today there are about 380 different antigens in 44 systems. More than half of them are considered rare, i.e. their frequency in the general population is less than 4/1000.
Research on the estimation of the age of immature children is one of the strong identity markers of our team, and has given it international recognition for nearly 20 years. In a forensic context, the challenge is to make the decision of the Justice system more reliable in order to qualify a crime or a homicide (reaching the age of fetal viability, foeticide or neonaticide, justified choice of one method rather than another). In an archaeo-thanatological context, the challenge is to understand and interpret modes of burial or choices of burial sites according to age categories, and to be able to discuss the socio-cultural aspects of age-dependent funeral rites.
As a "forensic science", forensic anthropology must meet strict methodological constraints with regard to the stakes of the conclusions drawn. The reliability of the analytical processing chains of remains (skeletonized or not) which leads to the estimation of the biological profile presented in a court of law is part of it, and an interdisciplinary approach integrating the recent advances in the field of Artificial Intelligence and machine learning is able to bring significant progress.
The Collège Interdisciplinaire de Balistique Lésionnelle " CIBLé " brings together scientists, physicians, and forensic experts from the police and gendarmerie in order to study body trauma related to ballistic impacts. Several members of our team are involved and collaborate on "historical" case studies, as well as on expert appraisals of current judicial cases. A photographic atlas and a database are being created, and annual workshops are organized during national and international scientific events (French Society of Legal Medicine days, FASE symposium). A synthesis book is being prepared for publication by 2027.
Of interest to the entire historical depth explored by our team, the characterization of bone trauma is a central issue in the study of an individual's skeletal remains.
The challenge of this project, initiated in 2021, is to characterize the respective contributions of medical imaging techniques (CT scan, MRI) and 3D surface acquisitions (laser or structured light scanner, photogrammetry) in the reading of VAB.