One of the specificities of our species is its great cultural diversity which, in the same way as genes, is transmitted from generation to generation, which raises the question: how do cultural differences between human populations interact with their biological diversity and vice versa?
Projects
Given its medical implications, which will be seen elsewhere, and in the light of high-throughput genomic sequencing, this project proposes an expert re-reading of the molecular genetics of immunogenic polymorphisms (erythrocyte blood group systems and systems involved in the immune response) with a view to contributing both to the understanding of the history and evolution of modern humans and to the evolutionary history of these genes in order to outline their phylogeny.
Human beings and microbes have a permanent and double-edged relationship. In the intestinal flora they complement each other and in some cases these microorganisms cause infectious diseases in humans.
This project is led by Maria De Grandis (PhD, CR EFS), Sylvie Fernandes (PhD, DR EFS) and Stéphanie Morin (PhD, CR EFS), with the technical support of Alexandra Grimaldi (Research Assistant EFS), Cécile Durousseau (Research Assistant EFS) and Thomas Granier (Research Assistant EFS)
In this project we are interested in red blood cell diseases and the vascular abnormalities in which they may be involved, with a particular focus on dyserythropoiesis and blood cell interactions in the circulation. Initially we will concentrate our efforts on sickle cell disease as a pathological model, then we will extend our methodology to explore other diseases, notably membrane diseases, in which potential defects in erythropoiesis have never been examined.
Our transfusion research is focused on improving transfusion products, with RBC as the primary focus.
This project is led by Julie Di Cristofaro (PhD, HDR, CR EFS), Christophe Picard, (MD, PhD, HDR, EFS) and Pascal Pedini (PharmD, PhD, EFS), it benefits from many collaborations, including that with the team of Pr Pascal Chanez (APHM, INSERM, C2VN).
Based on the data from the previous project, the main objective of this project is to define the biomarkers particularly involved in the phenomena of tolerance, inflammation and rejection in order to improve the diagnostic and therapeutic management of transfused, grafted or transplanted patients as well as their donor selection.