This project is led by Julie Di Cristofaro (PhD, HDR, CR EFS), Christophe Picard, (MD, PhD, HDR, EFS) and Pascal Pedini (PharmD, PhD, EFS), it benefits from many collaborations, including that with the team of Pr Pascal Chanez (APHM, INSERM, C2VN).
Projects
Based on the data from the previous project, the main objective of this project is to define the biomarkers particularly involved in the phenomena of tolerance, inflammation and rejection in order to improve the diagnostic and therapeutic management of transfused, grafted or transplanted patients as well as their donor selection.
The immunological safety of transfusions is based, among other things, on the compatibility of erythrocyte blood groups. Today there are about 380 different antigens in 44 systems. More than half of them are considered rare, i.e. their frequency in the general population is less than 4/1000.
While it will rely on the skills of established researchers in population genetics, biological anthropology and the history of epidemics, this axis also intends to open up to the skills of the "Corps, normes, santé" team in health law, ethics and odontology. Knowledge will gain in comprehensiveness through an exploration of the epidemic body in its multiple facets.
The horizon of understanding the epidemic phenomenon will also be broadened by taking into account data from soils understood as environmental reservoirs of pathogens and their vectors. The team wants to be a pioneer in this type of approach, which is still on the fringe of scientific approaches, whereas soils are undeniably important epidemic foci because of their preservation of bacterial traces for many years.