This program, which addresses questions of paleopathology and paleoepidemiology, deals with the health status of populations in the past and as such represents an important federating area for the team. In particular, it addresses the estimation of the impact of infections (visible or invisible on the bone) on the general health of immatures, in collaboration with colleagues of the GENGLOBE team (Hommes-Microbes project). This component on immatures, started in 2021, runs until 2025.
Projects
In this project, we focus on the study of evolution from a functional perspective, specifically focusing on the biological and behavioral changes that made efficient starch metabolism possible.
This research project devoted to evolutionary approaches is essentially from a functional perspective. This is a major and very dynamic issue in paleoanthropology research at the international level. We will pursue the deployment of modelling, simulation and biomechanical analysis approaches, as well as genomic approaches (in particular in collaboration with the GENGLOBE team), developed in the framework of national and international collaborations.
In close collaboration with colleagues from the GENGLOBE team (project "History of human-microbe interactions"), this project will focus on reconstructing and better understanding ancient epidemics. Both diachronic (from the metal ages to contemporary populations) and on a large geographical scale, this project will open to a strong international development.
The patrimonialization of the VAB, as approached by the SHS (archaeology, social anthropology and law), questions in particular the conflicts of use and appropriation of these remains. The BONES team is a forerunner in these issues and has been involved in the implementation and management of the PAOHCE Project (working group on the implementation of protocols for sampling and analysis of human bones and on the conservation of samples) since 2020 thanks to Y. Ardagna.
This project is led by Maria De Grandis (PhD, CR EFS), Sylvie Fernandes (PhD, DR EFS) and Stéphanie Morin (PhD, CR EFS), with the technical support of Alexandra Grimaldi (Research Assistant EFS), Cécile Durousseau (Research Assistant EFS) and Thomas Granier (Research Assistant EFS)
In this project we are interested in red blood cell diseases and the vascular abnormalities in which they may be involved, with a particular focus on dyserythropoiesis and blood cell interactions in the circulation. Initially we will concentrate our efforts on sickle cell disease as a pathological model, then we will extend our methodology to explore other diseases, notably membrane diseases, in which potential defects in erythropoiesis have never been examined.
Our transfusion research is focused on improving transfusion products, with RBC as the primary focus.