This approach consists in analyzing the human-environment interactions (natural and cultural environment) as well as the demographic processes (migrations, expansion, bottleneck, founder effect and drift) at the origin of the structuring of ancient and contemporary populations. It is based on the analysis of genetic markers, both neutral and sensitive to selective pressures.
This project, led by Harilanto Razafindrazaka (PhD, CR CNRS), follows a tradition of the laboratory which is the study of the genetic diversity of the populations of the Indian Ocean including the Comoros and Madagascar.
One of the specificities of our species is its great cultural diversity which, in the same way as genes, is transmitted from generation to generation, which raises the question: how do cultural differences between human populations interact with their biological diversity and vice versa?
Given its medical implications, which will be seen elsewhere, and in the light of high-throughput genomic sequencing, this project proposes an expert re-reading of the molecular genetics of immunogenic polymorphisms (erythrocyte blood group systems and systems involved in the immune response) with a view to contributing both to the understanding of the history and evolution of modern humans and to the evolutionary history of these genes in order to outline their phylogeny.
Human beings and microbes have a permanent and double-edged relationship. In the intestinal flora they complement each other and in some cases these microorganisms cause infectious diseases in humans.
