This project, led by Harilanto Razafindrazaka (PhD, CR CNRS), follows a tradition of the laboratory which is the study of the genetic diversity of the populations of the Indian Ocean including the Comoros and Madagascar.
Projects
One of the specificities of our species is its great cultural diversity which, in the same way as genes, is transmitted from generation to generation, which raises the question: how do cultural differences between human populations interact with their biological diversity and vice versa?
Given its medical implications, which will be seen elsewhere, and in the light of high-throughput genomic sequencing, this project proposes an expert re-reading of the molecular genetics of immunogenic polymorphisms (erythrocyte blood group systems and systems involved in the immune response) with a view to contributing both to the understanding of the history and evolution of modern humans and to the evolutionary history of these genes in order to outline their phylogeny.
Human beings and microbes have a permanent and double-edged relationship. In the intestinal flora they complement each other and in some cases these microorganisms cause infectious diseases in humans.
While it will rely on the skills of established researchers in population genetics, biological anthropology and the history of epidemics, this axis also intends to open up to the skills of the "Corps, normes, santé" team in health law, ethics and odontology. Knowledge will gain in comprehensiveness through an exploration of the epidemic body in its multiple facets.
The horizon of understanding the epidemic phenomenon will also be broadened by taking into account data from soils understood as environmental reservoirs of pathogens and their vectors. The team wants to be a pioneer in this type of approach, which is still on the fringe of scientific approaches, whereas soils are undeniably important epidemic foci because of their preservation of bacterial traces for many years.